By Rouslan G. Efremov, Leonid Sazanov (auth.), Leonid Sazanov (eds.)
The booklet comprises chapters written via leaders within the examine at the constitution and serve as of respiration advanced I. it is going to offer a concise and authoritative precis of the present wisdom on advanced I of respiration chains. This enzyme is imperative to power metabolism and is implicated in lots of human neurodegenerative ailments, in addition to in getting older. till lately it used to be poorly understood on a structural point, and this ebook will supply a well timed reference source. one of these publication used to be now not released formerly. The final time a minireview sequence on complicated I have been released used to be in 2001, and because then complicated I box replaced relatively dramatically.
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Additional info for A Structural Perspective on Respiratory Complex I: Structure and Function of NADH:ubiquinone oxidoreductase
De P. Hellwig Faculté de chimie, Laboratoire de spectroscopie vibrationelle et électrochimie des biomolécules, Université de Strasbourg, 1 rue Blaise Pascal, 67008 Strasbourg, France L. 1 T. Friedrich et al. Introduction The enzyme complexes of respiratory chains transform the energy released by a redox reaction into the energy of an ion gradient across the membrane, in which they are embedded. This gradient is used for energy-consuming processes such as ATP synthesis, active transport and motion.
Another approach towards the determination of electron tunneling in complex I was performed by Hayashi and Stuchebrukhov (2010). They used density functional theory and a semiempirical electronic structure model to determine the electron tunneling pathways and the strength of electronic coupling between the Fe/S clusters. Using this approach, specific amino acids were identified that could serve as electronic wires to connect neighboring Fe/S clusters. In this model, the entrance residue and the exit residue of the wire are always made up of the coordinating cysteine residues.
The slowly exchanging domain, for example has been related for several proteins to the initial folding core during the sequence of events leading to protein folding (Kim et al. 1993). In addition, medium and fast exchanging domains can be distinguished. 2 On the Mechanism of the Respiratory Complex I 33 The tool is thus useful for the study of large conformational changes. If the presence of nucleotides in the soluble part of the enzyme is to influence the membrane arm in order to control proton translocation, the overall structure of the enzyme may change together with the accessibility of the different domains.