Download A Structural Perspective on Respiratory Complex I: Structure by Rouslan G. Efremov, Leonid Sazanov (auth.), Leonid Sazanov PDF

By Rouslan G. Efremov, Leonid Sazanov (auth.), Leonid Sazanov (eds.)

ISBN-10: 9400741375

ISBN-13: 9789400741379

The booklet comprises chapters written via leaders within the examine at the constitution and serve as of respiration advanced I. it is going to offer a concise and authoritative precis of the present wisdom on advanced I of respiration chains. This enzyme is imperative to power metabolism and is implicated in lots of human neurodegenerative ailments, in addition to in getting older. till lately it used to be poorly understood on a structural point, and this ebook will supply a well timed reference source. one of these publication used to be now not released formerly. The final time a minireview sequence on complicated I have been released used to be in 2001, and because then complicated I box replaced relatively dramatically.

Show description

Read Online or Download A Structural Perspective on Respiratory Complex I: Structure and Function of NADH:ubiquinone oxidoreductase PDF

Best structural books

Active, Hybrid, and Semi-active Structural Control: A Design and Implementation Handbook

This finished instruction manual is designed to supply the reader with the data had to effectively enforce an energetic, hybrid or semi-active regulate method to a constitution, safeguarding it opposed to environmental forces reminiscent of wind or earthquakes. Written via major specialists in structural keep watch over, this book:Emphasises fail-safe concepts and validates their implementation via simulations.

Electrical Transmission and Substation Structures 2009: Technology for the Next Generation

This lawsuits comprises forty five papers awarded on the 2009 electric Transmisson and Stubstations constructions convention, held in citadel worthy, Texas, on November 8-12, 2009. the aim of the convention used to be to supply extra knowing of the electrical software via technical papers, workshops, plant excursions, and networking between application pros.

Structural crashworthiness and failure

This publication includes twelve invited lectures from the 3rd foreign Symposium on Structural Crashworthiness. specific emphasis is given to the failure predictions for ductile steel constructions less than huge dynamic rather a lot and to the behaviour of composite and mobile buildings.

Slope stability engineering : developments and applications : proceedings of the International Conference on Slope Stability

This quantity attracts at the adventure and wide examine of a global authorship to collect information on slope balance, motives of landslides, landslide prevention, new thoughts for assessing and predicting balance, new tools for stabilising slopes and the distinct issues for coastal occasions

Additional info for A Structural Perspective on Respiratory Complex I: Structure and Function of NADH:ubiquinone oxidoreductase

Example text

De P. Hellwig Faculté de chimie, Laboratoire de spectroscopie vibrationelle et électrochimie des biomolécules, Université de Strasbourg, 1 rue Blaise Pascal, 67008 Strasbourg, France L. 1 T. Friedrich et al. Introduction The enzyme complexes of respiratory chains transform the energy released by a redox reaction into the energy of an ion gradient across the membrane, in which they are embedded. This gradient is used for energy-consuming processes such as ATP synthesis, active transport and motion.

Another approach towards the determination of electron tunneling in complex I was performed by Hayashi and Stuchebrukhov (2010). They used density functional theory and a semiempirical electronic structure model to determine the electron tunneling pathways and the strength of electronic coupling between the Fe/S clusters. Using this approach, specific amino acids were identified that could serve as electronic wires to connect neighboring Fe/S clusters. In this model, the entrance residue and the exit residue of the wire are always made up of the coordinating cysteine residues.

The slowly exchanging domain, for example has been related for several proteins to the initial folding core during the sequence of events leading to protein folding (Kim et al. 1993). In addition, medium and fast exchanging domains can be distinguished. 2 On the Mechanism of the Respiratory Complex I 33 The tool is thus useful for the study of large conformational changes. If the presence of nucleotides in the soluble part of the enzyme is to influence the membrane arm in order to control proton translocation, the overall structure of the enzyme may change together with the accessibility of the different domains.

Download PDF sample

Rated 4.98 of 5 – based on 7 votes