Toxicology

Download A world-wide yearly survey of new data and trends in adverse by J.K. Aronson (Eds.) PDF

By J.K. Aronson (Eds.)

ISBN-10: 0444509992

ISBN-13: 9780444509994

The unwanted effects of gear Annual was once first released in 1977. it's been released continually because then, as a every year replace to the encyclopaedic quantity Meyler's uncomfortable side effects of substances. each one new Annual presents clinicians and clinical investigators with a competent and important each year survey of latest facts and tendencies within the region of difficult Drug Reactions and Interactions.

a world crew of experts have contributed to the Annuals through picking out seriously from every one year's courses all that's actually new and informative, through significantly analyzing it, and by way of mentioning no matter what is deceptive. using the e-book is better by way of separate indexes, permitting the reader to go into the textual content through the drug identify, antagonistic impact, or drug interaction.

specified positive aspects of the Annuals are the negative effects of gear Essay, often written via a visitor writer, and the designated stories: brief articles, in the assorted chapters, that supply additional recognition to subject matters of present interest.

The Essay in Annual 26 is entitled 'How secure is cannabis?' (by Professor L.L. Iversen) and there's a historic Essay entitled 'From thalidomide to pharmacovigilance: a private account' (by Professor D.J. Finney).

The exact stories during this quantity comprise, between others:

  • The cognitive results of Ecstasy
  • Antipsychotic medications and weight gain
  • Vigabatrin-related visible abnormalities
  • Managing the adversarial results of morphine
  • The cardiotoxic results of antihistamines
  • Inhaled corticosteroids and development inhibition in children
  • Bioterrorism and its prevention via immunization

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Additional info for A world-wide yearly survey of new data and trends in adverse drug reactions

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Treatment of pregnant rabbits with THC at doses up to 5 mg/kg had no effect on birth weight and did not cause any abnormalities in the offspring (10ER ). A similarly detailed toxicology study was carried out with THC by the National Institute of Environmental Health Sciences in the USA, in response to a request from the National Cancer Institute (11E ). Rats and mice were given THC up to 500 mg/kg 5 times a week for 13 weeks; some were followed for a period of recovery over 9 weeks. By the end of the study more than half of the rats treated with the highest dose (500 mg/kg) had died, but all of the remaining animals appeared to be healthy, although in both species the higher doses caused lethargy and increased aggressiveness.

31. Patwary KW. Report on Statistical Aspects of the Pilot Project for International Drug Monitoring. Geneva: World Health Organization, 1969. 32. Finney DJ. Systematic signalling of adverse reactions to drugs. Methods Inf Med 1974; 13: 1–10. 33. Finney DJ. The detection of adverse reactions to therapeutic drugs. Stat Med 1982; 1: 153–61. 34. Finney DJ. Report–Record–Detect–Interpret– Inform. In: Boström H, Ljungstedt N (editors). Detection and Prevention of Adverse Drug Reactions. Skandia International Symposia.

David J. Finney the raw data was essential. Individual acknowledgment of every report received was scarcely needed, but I believed that the CSD ought to have done more than it did to interact with doctors and the public (33, 34). If we are to have a flow of therapeutic improvements by the introduction of new drugs, adverse reactions that could not have been predicted by a pharmacologist nor always observed during the routine of clinical trials will inevitably sometimes occur. I have emphasized (35) the importance of regular communication between a national monitoring agency, the drug industry, doctors, and the public, in order to increase understanding of problems that are common to all.

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