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Ductal carcinoma in situ is sometimes detected as a palpable lump, but because DCIS grows within the confinement of preexisting ducts, the formation of a lump is not frequent and DCIS is usually detected only at screening mammography. Mammographically, DCIS is characterized by typical patterns of microcalcifications. When breast cancer is detected by screening mammography, DCIS constitutes 20% of all cancers, whereas it constitutes only 3% in non-screen-detected cancers. ,1990). Therefore the treatment of choice is mastectomy, as this will remove all tumor and usually leads to complete cure.
Clin. Oncol. 11, 145. Bertram, J. , Kolonel, L. , and Meyskens, F. , Jr. (1987). Cancer Res. 47,3012-3031. , Paganelli, G. , and Barbara, L. (1990). Cancer Res. 50, 1156-1 159. Block, G. (1991). J. Clin. Nufr. 53, 270s-282s. Boone, C. , Kelloff, G. , and Malone, W. F. (1990). Cancer Res. 50, 2-9. Boring, C. , Squires, T. , and Tong, T. (1992). ]. Clin. 2(1), 19-38. Cohen, L. , Kendall, M. , ef al. ]. Natl. Cancer Inst. 83,496-500. De Cosse, J. ,and Lesser, M. L. ]. Natl. Cancer Inst. 81, 1290-1297.
1987a), and it is tempting to speculate that this HSR corresponds to the chromosomal region containing theflg gene. Amplification offlg is associated with the presence of amplification of the 1lq13 region. 5% of breast carcinomas and is more frequently encountered in tumors that also harbor c - m y gene amplification. MOLECULAR GENETICS IN BREAST CANCER 39 B. POINTMUTATIONS T h e only point mutations thus far detected in human cancer are those in the rm family of genes, in the p53 gene and in the prohibitin gene (for the latter two, see Section 11,D).