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Download Advances in Low-Temperature Biology, Volume 3 by Peter L. Steponkus PDF

By Peter L. Steponkus

ISBN-10: 0762301600

ISBN-13: 9780762301607

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Extra info for Advances in Low-Temperature Biology, Volume 3

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1974) contained neither an impermeant ion to control cell swelling generally nor a colloid to raise the oncotic pressure of the intravascular space and restrict interstitial edema. This lack of control of hydration during hypothermic exposure would Hypothermic Protection During Bloodless Surgery 43 undoubtedly have contributed to poor preservation of cellular integrity and deleterious increases in tissue edema, particularly noted in the lungs. It was mentioned earlier that the lungs are especially vulnerable to congestion and edema during cardiopulmonary bypass, even without adjunctive hypothermia, and the dog is particularly sensitive to this problem rendering the canine model a critical test for strategies designed to avoid these complications (Sealy, 1989).

Of the remaining ten dogs, one died after four days of neurological complications (seizures) and another died of a severe blood transfusion reaction ten days post-operatively. The remaining eight dogs survived long term (30 to 86 days) before elective sacrifice; two were free of any detectable neurological complications, but the rest had transient neurological deficits, which related predominantly to hind limb weakness, transient circling behavior, and decreased vision. ff Revived # Not Revived T3 c 0) E Ir -rf Group I Group 11 Nadir Temp.

1992b). Another characteristic of "intracellular-type" preservation solutions that has been proposed, tested and debated has been the ionic balance. Conceptually, it has been argued that a hyperkalemic solution would be beneficial by inhibiting the passive exchange of monovalent cations across cell membranes during hypothermic exposure when active membrane pumps are suppressed. , 1985; 1989)). With reference again to the earlier attempts by Kondo et al.

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