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Download Advances in Pharmacology and Chemotherapy Volume 17 by Silvio Garattini PDF

By Silvio Garattini

ISBN-10: 0080581080

ISBN-13: 9780080581088

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Extra resources for Advances in Pharmacology and Chemotherapy Volume 17

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By this means we have shown that in the presence of methyl benzoquate or clopidol, development of E. tenella is held up at the intracellular sporozoite stage (Ryley, 1967), while in the presence of robenidine, large multinucleate first generation schizonts accumulate, but are unable to proceed to merozoite differentiation (Ryley and Wilson, 1971). Similar studies have been reported with a number of other drugs (Ryley and Wilson, 1975, 1976b; Ryley e? ,1974). In order to detect by histological means inhibited first generation parasites, it is necessary to use massive inocula of coccidia; in order to be relevant to the field situation, the recommended level of drugs should be used.

37 41 41 45 50 50 57 66 68 74 76 80 80 83 86 87 87 87 90 91 91 92 92 92 93 94 . 1 Introduction Dihydrofolate reductase (DHFR) (tetrahydrofolate N A D P oxidoreductase. 5. 3) catalyzes the NADPH-dependent reduction of 7. 8. 7. tetrahydrofolate (THF) (see Fig . 1): DHF + NADPH + H+ THF + NADP (1) THF is a coenzyme in a number of 1-carbon transfer reactions (Rader and 37 Copyright 0 1980 by Academic Press.

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