By Silvio Garattini
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Additional info for Advances in Pharmacology and Chemotherapy Volume 19
3hydroxy, 4%; trcrris -3-hydroxy, 23%; and trtrns-2-hydroxy, 8%. During this period, 96% of the CCNU was metabolized (Hilton and Walker, 25 CHLOROETHYLNITROSOUREA 1975b). In addition to ring hydroxylation, thioacetic acid has been identified as a major urinary product from [ l''C]chloroethyl-CCNU (Reed and May, 1975). Phenobarbital also altered the distribution of hydroxylated metabolites in i i \ * o . Two minutes after CCNU administration, cis -4hydroxy CCNU was the major metabolite, 62%, along with significant amounts ofturuT-3-hydroxy CCNU, 2 l V (Hilton and Walker, 1975).
Zito. D. , and Walker, M. D. (1977). \. 37, 2262-2266. , and Sargent, S. (1978). Riochetn. Phrrrmtrcol. 27. 1359-1363. Hung, D. , Deen, D. , and Marton, L. J. (1981). Ctrnrcv R t l . 41, 27832785. Johnston, T. , and Opliger, P. S. J . M d . Clrrni. 10, 675-681. Johnston, T. , McCaleb, G . , and Montgomery, J . A. (1963). J . M e d . Clrrrn. 6, 669-681, Johnston, T. , McCaleb, G . , Opliger, P. , and Montgomery, J. A. (1966). J . Mrci. Cheor. 9 , 892-91 I . Johnston, T. , McCaleb, G . , Opliger, P.
The effect of anticancer chemotherapeutic agents on tumor-associated macrophages has been the object of limited investigation and available data will be discussed in the second part of this article. Finally, I will examine the relationship between interaction with cells of the monocyte-macrophage series and antineoplastic efficacy, with emphasis on the antitumor efficacy of combined chemoimmunotherapy approaches with immunomodulatory compounds with macrophage stimulatory properties. II. Effects of Chemotherapeutic Agents on Mononuclear Phagocytes A.